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Journal of Medical Sciences

Year: 2001  |  Volume: 1  |  Issue: 4  |  Page No.: 220 - 223

Characterization and In vitro Antimicrobial Activity of the Two Novel Compounds of Streptomyces Species

A. S. M. Anisuzzaman, Naoki Sugimoto, S. A. Bhuiyan, Golam Sadik and M. A. Gafur


The objective of this investigation is to determine the in vitro antimicrobial activity of the two novel compounds from Streptomyces. This antagonistic micro-organism was isolated and identified on the basis of morphological and biochemical study from the soil of the Northern district of Pabna, Bangladesh. The organism yielded maximum antimicrobial principle when grown at Czapek-Dox broth medium of pH 8 for 8 days at temperature 37.5C having rhamnose as carbon source. The antimicrobial principles were extracted from the fermentation broth by choloroform. The extract on chromatographic resolution yielded two antimicrobial compounds: Streptomysone-A (I) and Streptomysone-B (II). Both the compounds were screened for antimicrobial activity against eighteen pathogenic organisms which showed moderate to strong antimicrobial activity. The minimum inhibitory concentration (MIC) of the compounds against five pathogenic organisms were found to be between 32 to 128μg ml‾1.

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