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Journal of Medical Sciences
Year: 2001  |  Volume: 1  |  Issue: 4  |  Page No.: 214 - 216

In vitro Antibacterial Activity of the Compounds of Trapa bispinosa Roxb

M. Motiur Rahman, Mir Imam Ibne Wahed, M. Helal U. Biswas, Md. GolamSadik and M. Ekramul Haque    

Abstract: The research work was conducted to investigated the in vitro antibacterial activity of the compound isolated from Trapa bispinosa. Antibacterial activity of the compounds was observed against fifteen pathogenic organisms (both Gram positive and Gram negative Bacteria) by disc diffusion method. Compound MTC-4 isolated from chloroform extract showed significant in vitro antibacterial activity against almost all of the test organisms but maximum activity showed against Bacillus subtilis and shigella  dysenteriae and produced zone of inhibition in between 12 to 15mm. While the compound MTE-1 showed moderate activity (08 to 12mm) against most of the test organisms. The other two compounds MTC-3 and MTC-5 were found comparatively less active. The MIC values of the compounds were also determined against two test organisms Bacillus subtilis and Shigella dysenteriae. The values were found to be between 8 to 128μg ml‾1. Thus MTC-4 possesses strong antibacterial activity and suggested its therapeutic use as an antimicrobial agent.

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