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Research Journal of Microbiology
Year: 2016  |  Volume: 11  |  Issue: 2-3  |  Page No.: 93 - 100

Alternative Antibiotics Source from Symbiont of Lactid Acid Bacteria Inside Stomach of Honeybees (Apis mellifera and Apis dorsata) Against Multiresistant Antibiotics Pathogenic Bacteria

Novra Arya Sandi and Siti Isrina Oktavia Salasia    

Abstract: Honey is natural food that common used directly by the society. Forest honey produced by wild bees (Apis dorsata) while the other type of honey produced by Apis mellifera. Beekeeping A. mellifera with monoflora or multiflora nectar is generally carried out by various countries including Indonesia. Scientifically, honey containing bioactive compounds with antimicrobial properties but still uncertain which compounds that play a role in these activities. Reported bioactive compounds that have antibacterial activity of honey are inhibine and non-inhibine. Inhibine is forming enzyme and accumulation of hydrogen peroxide (H2O2) to dilute honey and nectar. The H2O2 has also long been known as an effective antibacterial and major component of penicillin, especially notatin. The types of antibacterial compounds influenced by nectar-source plants with compounds including alkaloids, flavonoids and glycosides. Some researchers reported that beside phytochemicals, antibacterial activity due to presence of Lactic Acid Bacteria (LAB) that produce bioactive compounds with antibiotic-like activity. Some studies reported 3 LAB strains potential to produce bioactive compounds with activity resembles antibiotics, namely L. kunkeei Fhon2, L. kunkeei Lahm and L. kunkeei Yubipro with the greatest inhibition zones than other Lactobacillus. Honeybees are isolated from the stomach LAB capable of producing organic acids, free fatty acids, ethanol, benzoic acid, enzymes, H2O2 and antimicrobial peptides. Different character of the bioactive compounds will jointly deliver results on inhibition zone and broad spectrum for various types of microbial pathogens. Microbial pathogens tested including Serratia marcescens, Klebsiella aerogenes, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and methicilin resistant Staphylococcus aureus (MRSA).

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