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Research Journal of Microbiology
Year: 2011  |  Volume: 6  |  Issue: 10  |  Page No.: 761 - 768

Antibacterial Activity of Cycas rumphii Miq. Leaves Extracts against Some Tropical Human Pathogenic Bacteria

Abdul Viqar Khan, Qamar Uddin Ahmed, Athar Ali Khan and Indu Shukla    

Abstract: Cycas rumphii is traditionally used to cure wide variety of ailments including malignant ulcers, wounds healing, sore throats and tuberculosis showing its great potential as an antimicrobial agent. Hence, aim of the present study was to explore antibacterial potential of the leaves of C. rumphii Miq. Dried leaves were separately macerated with methanol and double distilled water at room temperature to obtain methanol and aqueous (AQ) extracts. The methanol extract was further successively extracted with light petroleum ether (LPE), benzene (BZ), ethyl acetate (EtOAc) and methanol (MeOH) on hot water bath to get respective extracts. These extracts were evaluated for their antibacterial efficacy at six different concentrations (500 μg, 1, 2, 5, 10 and 15 mg mL-1) against seven G+ve and eleven G–ve hospital isolated bacterial strains causing several tropical diseases using disc diffusion method. EtOAc and MeOH extracts showed maximum antibacterial activity against most of the bacteria taken into account. The most susceptible Gram positive bacteria was S. albus with inhibition zone of 22 mm while most susceptible Gram negative bacteria was S. boydii with 21 mm inhibition zone with EtOAc extract while the most resistant bacteria was gram negative S. typhi. Present findings are suggestive of antibacterial agents in the leaves of C. rumphii which can be used in future for formulation of broad spectrum herbal antibacterial products. Results of present study also support various traditional uses associated with this plant which were suggestive of possible antibacterial potential of this plant. Hence, EtOAc and MeOH extracts of the leaves of C. rumphii deserve further investigations.

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