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Research Journal of Microbiology
Year: 2007  |  Volume: 2  |  Issue: 6  |  Page No.: 524 - 529

Antimutagenic Effect of Lactobacillus acidophilus and Lactobacillus bulgaricus Isolated from Iranian Yoghurt on 2-Nitrofluorene

Ashraf Mohabati Mobarez, Reza Hosseini Doust, Zuhair Mohamad Hassan and Saminea Kamali    

Abstract: The antimutagenic activity of Lactobacillus bulgaricus and acidophilus to potent mutagen, 2-nitrofluorene was examined by the modified Ames test using Salmonella typhimurium TA100. The results showed that the supernatants, heat killed cells and viable cells of Lactobacilli, preincubated with mutagenic factor such as 2-nitrofluorene, displayed characteristic antimutagenic activities. L. bulgaricus and L. acidophilus cells showed 98 and 64% antimutagenic activity against 2-nitrofluorene, respectively. Antimutagenic activities of Lactobacilli were higher than their supernatants. All the strains, heated for 15 min at 100°C, antimutagenic activities were reduced by 36-47%.

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