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Research Journal of Microbiology
Year: 2007  |  Volume: 2  |  Issue: 4  |  Page No.: 303 - 314

Morphological and Ultrastructural Studies for the Biological Action of Penicillic Acid on Some Bacterial Species

S.M. Ezzat, E.A. El-Sayed, M.I. Abou El-Hawa and A.A. Ismaiel    

Abstract: Nine species of bacteria were tested for sensitivity against Penicillic Acid (PA) using a disc diffusion assay. Among the tested bacterial species, Salmonella typhi appeared to be the most sensitive bacteria. Bacillus cereus showed the less response to the inhibitory effect of PA. The response of treated cells of S. typhi and B. cereus to PA was detected using light and electron microscopic examination. PA induced the formation of flattened and filamentous cells due to increase in lengths and widths of cells. This was more clear in treated cells of S. typhi than those of B. cereus. The cell wall and cytoplasmic membrane of S. typhi appeared to be damaged and a part of cytoplasmic material may be released through cracks. Moreover, deformation in the submicroscopic structure of S. typhi cells that treated with PA have been observed and some cells showed an irregularity in shape. Examination of the ultrathin sections of the treated B. cereus cells with PA, indicated that mature stainable sporangial formation in most cells and developmental stages of sporulation are obtained at a faster rate compared with those of growing vegetative control cells. Studying the antibacterial activities of PA were extended to show bacteria that resistant to some conventional antibiotics, were being sensitive to the saturated antibiotic discs with PA.

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