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Japanese Journal of Clinical Oncology
Year: 2010  |  Volume: 40  |  Issue: 7  |  Page No.: 699 - 701

Phase II Study of Combination Chemotherapy with Biweekly Cetuximab and Irinotecan for Pre-treated Metastatic Colorectal Cancer Harboring Wild-type KRAS

K Shitara, T Yokota, D Takahari, T Shibata, T Ura, Y Komatsu, S Yuki, M Yoshida, H Takiuchi, S Utsunomiya, Y Yatabe and K. Muro    


Standard weekly cetuximab and irinotecan is an effective regimen in heavily pre-treated patients with metastatic colorectal cancer. The aim of this study is to prospectively evaluate the efficacy of combination chemotherapy with biweekly cetuximab and irinotecan in patients with pre-treated metastatic colorectal cancer harboring wild-type KRAS. A total of 30 patients will be enrolled at four medical institutions. The primary endpoint is response rate. The secondary endpoints include adverse events, progression-free survival and overall survival. The pharmacokinetics of cetuximab will also be evaluated in five patients.

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