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Japanese Journal of Clinical Oncology
Year: 2010  |  Volume: 40  |  Issue: 3  |  Page No.: 222 - 226

Disturbance of the Growth Hormone-Insulin-like Growth Factor-1 Axis Associated with Poor Performance Status in Patients with Solid Tumors

I Okamoto, M Munakata, M Miyazaki, T Satoh, T Takahata, Y Takamatsu, O Muto, K Koike, K Ishitani, T Mukaiyama, Y Sakata, K Nakagawa and K. Tamura    

Abstract: Objective

Hormonal imbalance characterized by excessive production of growth hormone (GH) and a low circulating concentration of insulin-like growth factor (IGF)-1 has been demonstrated in individuals with various serious conditions. However, little is known about changes in the GH–IGF-1 axis in cancer patients.

Methods

We prospectively examined the circulating levels of several hormones in 58 patients with solid tumors who were classified according to Eastern Cooperative Oncology Group performance status (PS): PS 0–1, n = 15; PS 2, n = 15; PS 3, n = 15; and PS 4, n = 13. The relations of hormone concentrations, with a focus on the GH–IGF-1 system, to PS were evaluated by Spearman's rank correlation test and regression analysis.

Results

The circulating levels of IGF-1, IGF-binding protein-3 and thyroid hormones (total T3 and T4) were inversely correlated with PS score. The concentration of GH was increased irrespective of PS but not statistically significant. The ratio of IGF-I to GH was inversely correlated with PS. The levels of GH and IGF-1 in all patients were also inversely correlated.

Conclusions

The present study suggests that the GH–IGF-1 axis is disturbed in patients with cancer.

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