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Journal of Fisheries and Aquatic Science
Year: 2016  |  Volume: 11  |  Issue: 2  |  Page No.: 131 - 146

Glutathione-Enhancer™ Against Foodborne Aflatoxicosis of Oreochromis niloticus (Linnaeus, 1758)

Ahmed I. Mehrim, Mohamed M. Refaey and Khaled M. Elmeleigy    

Abstract: Aflatoxicosis is the poisoning that caused by aflatoxins in both humans and animals including fish. The present study aimed to investigate the capability of dietary Glutathione-enhancer™ (GSH-En) to detoxify the chronic toxic effects of aflatoxin B 1 (AFB 1) on Oreochromis niloticus for 10 weeks. Fish with an average initial body weight of 28.75±0.14 g were distributed into five treatments (three replicates in each). The AFB 1 was added at a concentration of 150 μg kg–1 diet to all mash Basal Diet (BD) (T 2 C+,T 3, T 4 and T 5), except AFB 1-free mash BD was considered as a negative control (T 1 C-) group. AFB 1-BD was considered as a positive control (T 2 C+). However, graded levels (50, 100 and 200 mg GSH kg–1 diet) as GSH-En were added to AFB 1-BD T 3, T 4 and T 5, respectively. The results revealed the adverse impacts of AFB 1 (T 2 C+) on growth and feed efficiency, fish carcass composition, condition factor and hepato-somatic index, hematological and serum biochemical parameters, reduction in tissues content of glutathione reduced and total antioxidant capacity, hepatic histological alterations, besides AFB 1-bioaccumulation in the tissues among all toxic groups. Dietary GSH-En was more effective to alleviate these toxicological effects of AFB 1, increasing levels dependent. Hence, it could be concluded that efficient use of GSH-En as a food additive, especially into the high level (200 mg kg–1 diet) against the toxicity of AFB 1 on O. niloticus. Also, dietary addition of GSH-En at this level may lead to access to safe fish product for human consumption and create more friendly-environment conditions for both fish production and human health.

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