Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Fisheries and Aquatic Science
Year: 2016  |  Volume: 11  |  Issue: 2  |  Page No.: 131 - 146

Glutathione-Enhancer™ Against Foodborne Aflatoxicosis of Oreochromis niloticus (Linnaeus, 1758)

Ahmed I. Mehrim, Mohamed M. Refaey and Khaled M. Elmeleigy    

Abstract: Aflatoxicosis is the poisoning that caused by aflatoxins in both humans and animals including fish. The present study aimed to investigate the capability of dietary Glutathione-enhancer™ (GSH-En) to detoxify the chronic toxic effects of aflatoxin B 1 (AFB 1) on Oreochromis niloticus for 10 weeks. Fish with an average initial body weight of 28.75±0.14 g were distributed into five treatments (three replicates in each). The AFB 1 was added at a concentration of 150 μg kg–1 diet to all mash Basal Diet (BD) (T 2 C+,T 3, T 4 and T 5), except AFB 1-free mash BD was considered as a negative control (T 1 C-) group. AFB 1-BD was considered as a positive control (T 2 C+). However, graded levels (50, 100 and 200 mg GSH kg–1 diet) as GSH-En were added to AFB 1-BD T 3, T 4 and T 5, respectively. The results revealed the adverse impacts of AFB 1 (T 2 C+) on growth and feed efficiency, fish carcass composition, condition factor and hepato-somatic index, hematological and serum biochemical parameters, reduction in tissues content of glutathione reduced and total antioxidant capacity, hepatic histological alterations, besides AFB 1-bioaccumulation in the tissues among all toxic groups. Dietary GSH-En was more effective to alleviate these toxicological effects of AFB 1, increasing levels dependent. Hence, it could be concluded that efficient use of GSH-En as a food additive, especially into the high level (200 mg kg–1 diet) against the toxicity of AFB 1 on O. niloticus. Also, dietary addition of GSH-En at this level may lead to access to safe fish product for human consumption and create more friendly-environment conditions for both fish production and human health.

Cited References   |    Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility