Abstract: Haematology is important in order to know the state of health of fish species. Some haematological parameters of inter-generic hybrids African catfish (Clarias anguillarisx Heterobranchus bidorsalis) were investigated in North east Nigeria. The study aimed at investigating the haematological competence of the hybrids for survival in culture conditions in the region. Most fish farmers in the North east shade their ponds concrete of earthen due to stress as a result of harsh weather conditions in the region. Red Blood Cells (RBC) were significantly higher (2.46±0.03x10³ μL^-1) in hybrid CaxHb (Heteroclarias). However, MCV and MCH were significantly (p<0.05) higher (138.07±1.98 fl and 46.53±0.70 pg, respectively) in pure line of Heterobranchus bidorsalis. MCHC values of pure line C. anguillaris and their maternal hybrids ♀CaxHb♂ (30.03±1.96 and 35.23±0.62 g dL^-1, respectively) varied significantly (p<0.05) from those of Heteroclarias (34.57±0.33 g dL^-1). However, all the blood parameters of fish species recorded during this study were within the healthy ranges for fish. The results of this study show that Heteroclarias have more haematological competence for survival in culture conditions in the North east region.