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Journal of Engineering and Applied Sciences
Year: 2018  |  Volume: 13  |  Issue: 12  |  Page No.: 4300 - 4304

Indirect Response of Early Mouse Embryo to Oxidative Stress Evoked in Apoptosis Model

A.G. Pogorelov, O.A. Suvorov, V.M. Bakhir, A.I. Panait, M.A. Pogorelova and G.R. Ivanisky    

Abstract: Quantitative laser microtomography was employed to measure the single cell volume. NMRI mouse zygotes and 2-cell embryos were shown to exhibit the shrinkage at apoptosis induced with ROS (40 min., H2 O2 , 0.2 mM). Unlike early embryos, there was no influence of in vitro apoptotic circumstances on mature oocytes, direct precursor of early embryogenesis. Dulbecco’s solution prepared from electrochemically reduced bi-distilled water allows the low redox potential in both normal and apoptotic conditions. The data obtained permit us to suggest that ROS sub-milimolar concentrations likely act as the signaling impact. Cys-loo receptors containing thiol group may be considered as the target of hydrogen peroxide molecules.

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