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Journal of Engineering and Applied Sciences
Year: 2017  |  Volume: 12  |  Issue: 8  |  Page No.: 1992 - 1998

In Silico Potential Vaccine Against Outer Membrane Protein 2 in Haemophilus parasuis

Nazgol Emamian, Fateme Sefid, Vahide Saeidjavan, Sepide Akhgari and Hamed Karamizade    

Abstract: Haemophilus parasuis is a gram-negative bacterium belonging to the Pasteurellaceae family. This organism is an important respiratory-tract pathogen in swine and the etiological agent of porcine polyserositis, meningitis and arthritis syndrome known as Glasser’s disease. Among the 15 known serovars, serotype 5 shows high virulence and is one of the most prevalent serotypes. Attempts to control the H. parasuis infection are hindered by a lack of thorough knowledge of the virulence factors and protective antigens of the bacterium, the existence of diverse genetic make-ups and the evolution of multidrug-resistant strains. Initial studies about the immune response developed against H. parasuis have detected antibodies to Outer Membrane Proteins (OMPs) but not against lipopolysaccharide or capsule, suggesting that the OMPs are more immunogenic than other components of bacteria. In recent years, interest has shifted toward protein based vaccines. It has been shown that recombinant vaccines based on OMPs provided partial protection against challenge with H. parasuis.

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