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Journal of Clinical Lipidology
Year: 2012  |  Volume: 6  |  Issue: 5  |  Page No.: 462 - 468

Serum apolipoprotein A-V in patients with coronary artery disease and its association with triglyceride

Yang Yang, Shabbir M. Walijee, Jing Jin, Shui-ping Zhao and Dao-Quan Peng    

Abstract:

Background

Apolipoprotein A-V (ApoA-V) has been shown to play an important role in the metabolism of plasma triglyceride (TG) levels. However, data for the relationship between serum ApoA-V and TG level and the association between ApoA-V levels and the risk of coronary artery disease (CAD) are inconsistent.

Objective

To investigate plasma ApoA-V level and its association with TG in patients with CAD determined by angiography.

Methods

Three hundred forty subjects who underwent coronary angiography (CAG) were classified into a CAD group (n = 211) and a non-CAD group (n = 129) according to the results of their CAG. Serum ApoA-V levels were determined by enzyme-linked immunosorbent assays.

Results

Patients in the CAD group had greater ApoA-V levels than controls (192.0 114.6 ng/mL vs 164.4 107.5 ng/mL, P < .05). The concentration of ApoA-V was positively correlated to TG level (r = 0.229, P < .01). This correlation was more intense in non-CAD group (r = 0.306, P < .01) than in CAD group (r = 0.172, P < .05). ApoA-V was positively associated with Gensini score. However, the contribution of ApoA-V to Gensini score and CAD risk disappeared after adjustment for the TG level.

Conclusion

The positive correlation between serum ApoA-V and TG differs in strength between control and CAD patients. The correlation between ApoA-V and CAD is confounded by the effect of TG. We speculate that the increase of ApoA-V may be a consequence of compensation for the increased demand for plasma TG hydrolysis.

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