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Journal of Clinical Lipidology
Year: 2012  |  Volume: 6  |  Issue: 3  |  Page No.: 256 - 257

Reduction in Estimated 10-Year Coronary Heart Disease Risk Using Reynolds Risk Score: A Post-Hoc Analysis of Exenatide-Treated Patients with Diabetes

Elaine Chiquette, Gilbert Ramirez, Peter P. Toth, Michael Cobble, Brandon Walsh and Robert Chilton    

Abstract: The Reynolds Risk Score best-fitting model (RRS) estimates 10-year coronary heart disease (CHD) risk by incorporating an expanded number of risk markers, including A1C, systolic blood pressure, C-reactive protein (hsCRP), apolipoproteins, and the interaction of lipoprotein(a) and ApoB. Treatment of type 2 diabetes (T2DM) with the GLP-1 receptor agonist exenatide has been reported to improve A1C, body weight, blood pressure, and lipid profiles; however, evidence regarding the impact of exenatide on other apolipoproteins is limited.

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