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Journal of Coordination Chemistry
Year: 2011  |  Volume: 64  |  Issue: 22  |  Page No.: 3992 - 4005

Mixed-ligand manganese(II)-phenolate complexes: study of DNA cleavage, cytotoxic activity, and induction of apoptosis

En-Jun Gao, Ying Zhang, Lin Lin, Ren-Shu Wang, Lei Dai, Qi Liang, Ming-Chang Zhu, Mei-Lin Wang, Lei Liu, Wen-Xuan He and Yan-Jin Zhang    

Abstract: Two manganese complexes, [Mn(L1)2(dibe)2](L1) (1) and [Mn(L2)(dibe)2] (2) (where L1 = 2,2′-bipyridine (bipy), L2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells.

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