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Journal of Coordination Chemistry
Year: 2011  |  Volume: 64  |  Issue: 21  |  Page No.: 3792 - 3807

Ruthenium(II) complexes: structure, DNA-binding, photocleavage, antioxidant activity, and theoretical studies

Xian-Lan Hong, Zhen-Hua Liang and Mao-Hua Zeng    

Abstract: Two triazine-containing ruthenium(II) complexes, [Ru(dmb)2(pdpt)](ClO4)2 (dmb = 4,4′-dimethyl-2,2′-bipyridine, pdpt = 3-(pyridine-2-yl)-5,6-diphenyl-as-triazine) (1) and [Ru(dmb)2(pdtp)](ClO4)2 (pdtp = 3-(pyridine-2-yl)-as-triazino[5,6-f]phenanthrene) (2), were synthesized and characterized by elemental analysis, ES-MS, 1H NMR, UV-Vis spectra, and cyclic voltammetry; the crystal structure of 2 was determined by X-ray diffraction. DNA-binding behaviors of both complexes were studied by absorption titration, thermal denaturation, and viscosity measurements. The photoactivated DNA cleavage of plasmid pBR322 in the presence of 1 and 2 was explored through gel electrophoresis. Antioxidant activities of the two complexes against hydroxyl radical (·OH) were also investigated. The results indicate that the DNA-binding affinity of 2 is much greater than that of 1, and that 2 binds to calf thymus DNA by intercalation, but 1 binds in partial intercalation, with π−π stacking on the DNA surface. Experimental findings made through analysis of the CV, absorption spectra, X-ray crystal structure, and the DNA-binding properties were compared with those of theoretical studies using density functional calculations.

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