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The Journal of Cell Biology
Year: 2010  |  Volume: 188  |  Issue: 1  |  Page No.: 69 - 81

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

F. J Vizeacoumar, N van Dyk, F S.Vizeacoumar, V Cheung, J Li, Y Sydorskyy, N Case, Z Li, A Datti, C Nislow, B Raught, Z Zhang, B Frey, K Bloom, C Boone and B. J. Andrews    

Abstract:

A combination of yeast genetics, synthetic genetic array analysis, and high-throughput screening reveals that sumoylation of Mcm21p promotes disassembly of the mitotic spindle.

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