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The Journal of Cell Biology

Year: 2010  |  Volume: 188  |  Issue: 4  |  Page No.: 547 - 563

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

M Koivusalo, C Welch, H Hayashi, C. C Scott, M Kim, T Alexander, N Touret, K. M Hahn and S. Grinstein


Inhibitors of Na+/H+ exchange proteins block macropinocytosis by lowering the pH near the plasma membrane, which in turn inhibits actin remodeling by Rho family GTPases.

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