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The Journal of Cell Biology
Year: 2010  |  Volume: 189  |  Issue: 2  |  Page No.: 211 - 221

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

N Matsuda, S Sato, K Shiba, K Okatsu, K Saisho, C. A Gautier, Y. s Sou, S Saiki, S Kawajiri, F Sato, M Kimura, M Komatsu, N Hattori and K. Tanaka    

Abstract:

Defective mitochondrial quality control is shown to be a mechanism for neurodegeneration in some forms of Parkinson's disease.

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