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The Journal of Cell Biology
Year: 2010  |  Volume: 189  |  Issue: 1  |  Page No.: 111 - 126

Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

A. M Marchiando, L Shen, W. V Graham, C. R Weber, B. T Schwarz, J. R Austin, D. R Raleigh, Y Guan, A. J. M Watson, M. H Montrose and J. R. Turner    

Abstract:

Although tight junction morphology is not obviously affected by TNF, this proinflammatory cytokine promotes internalization of occludin, resulting in disrupted barrier function within the intestine.

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