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The Journal of Cell Biology

Year: 2010  |  Volume: 189  |  Issue: 1  |  Page No.: 111 - 126

Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

A. M Marchiando, L Shen, W. V Graham, C. R Weber, B. T Schwarz, J. R Austin, D. R Raleigh, Y Guan, A. J. M Watson, M. H Montrose and J. R. Turner

Abstract

Although tight junction morphology is not obviously affected by TNF, this proinflammatory cytokine promotes internalization of occludin, resulting in disrupted barrier function within the intestine.

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