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The Journal of Cell Biology
Year: 2009  |  Volume: 187  |  Issue: 5  |  Page No.: 715 - 731

New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control {beta}3-integrin clustering

F Saltel, E Mortier, V. P Hytonen, M. C Jacquier, P Zimmermann, V Vogel, W Liu and B. Wehrle Haller    

Abstract:

A talin intermolecular interaction autoinhibits its own activation and regulates β3-integrin binding. When bound, β3-integrin undergoes structural alterations that prevent its β and subunits from associating, maintaining β3-integrin's clustering capability.

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