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The Journal of Cell Biology
Year: 2009  |  Volume: 187  |  Issue: 5  |  Page No.: 623 - 635

Decreased replication origin activity in temporal transition regions

Z Guan, C. M Hughes, S Kosiyatrakul, P Norio, R Sen, S Fiering, C. D Allis, E. E Bouhassira and C. L. Schildkraut    


Experimental attempts to activate replication origins within the temporal transition region in the IgH locus in mouse embryonic stem cells were not successful, and thus, why and how they become activated in B cells remains unclear.

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