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The Journal of Cell Biology
Year: 2009  |  Volume: 187  |  Issue: 4  |  Page No.: 481 - 496

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET

D Lleres, J James, S Swift, D. G Norman and A. I. Lamond    

Abstract:

FRET analysis of cell lines expressing fluorescently tagged histones on separate nucleosomes demonstrates that variations in chromosome compaction occur during mitosis.

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