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Journal of Biological Sciences
Year: 2019  |  Volume: 19  |  Issue: 1  |  Page No.: 34 - 39

Caesalpinia pulcherrima Extracts on Blood Glucose in Normal and Alloxan Monohydrate-induced Diabetic Rats

Manoj Ramesh Kumbhare and Thangavel Sivakumar    

Abstract: Background and Objective: Type 2 Diabetes Mellitus is a long term endocrine metabolic disorder that is described by elevated blood sugar, insulin resistance and deficiency of insulin. Due to low toxicities and cost effectiveness natural products are comparatively safe and good source of effective antidiabetic agents. The present study designed to evaluate the effects of Caesalpinia pulcherrima extracts on blood glucose in normal and alloxan monohydrate-induced diabetic rats. Materials and Methods: Albino rats of Wistar strain (150-200 g) of either sex were used in the entire study. After randomization into various groups and before initiation of experiment, the rats were acclimatized for a period of 7 days under standard environmental conditions of temperature, relative humidity and dark/light cycle. Animals described as fasting were deprived of food for 16 h and water ad libitum. Sample collection-blood samples were collected by retro-orbital plexus puncture method and blood glucose levels were estimated using an electronic glucometer. Results: Three weeks of daily treatment of Alloxan induced methanolic extract of Caesalpinia pulcherrima at dose 400 mg kg1 led to a dose dependent fall in blood sugar levels from 290-233 mg dL1 in 21 days (Group 6). Conclusion: Extracts of pods of C. pulcherrima are capable of exhibiting reduction in blood glucose level in normal and alloxan monohydrate-induced diabetic rats.

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