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Journal of Biological Sciences
Year: 2018  |  Volume: 18  |  Issue: 8  |  Page No.: 475 - 487

Evaluation of Hepatoprotective, Antioxidant and Cytotoxic Properties of Isolated Flavonoids from Breynia disticha J.R.Forst. and G.Forst

Nagwa M. Ammar, Seham S. El Din El-Hawary, Amira A. El Anssary, Rehab M. Seif El-Din Ashour, Ahmed H. Afifi, Abeer A.A. Salama, Noha Nazeeh and Mohamed M. Ayoub    

Abstract: Background and Objectives: Breynia disticha J.R.Forst. and G.Forst is a tropical shrub widely grown in tropical Africa. The leaves have characteristic green, purple and pink color, found in gardens and public areas. The aim of the study was to investigate phytochemical and biological activities of successive extracts of aerial parts of Breynia disticha J.R.Forst. and G.Forst, cultivated in Egypt. Materials and Methods: Collection and taxonomical identification of the plant. Biological screening of successive extracts of Breynia disticha J.R. Forst. and G. Forst. and structural elucidation of compounds isolated by using different spectral techniques. Results: Two new flavonoids, quercetin 3-O-β-D-xylopyranoside (1→6) β-D-galactopyranoside along with its analogue kaempferol 3-O-β-D-xylopyranoside (1→6) β-D-galactopyranoside were isolated from 70% aqueous methanol extract of aerial parts of Breynia disticha J.R.Forst. and G.Forst. The chemical structures of the two compounds were elucidated by NMR spectroscopic analysis. Quercetin 3-O-β-D-xylopyranoside (1→6) β-D-galactopyranoside showed significant antioxidant and cytotoxic activities against hepatocellular carcinoma compared by its analogue. Also the polar fraction showed hepatoprotective activity by reducing elevated serum ALT level, AST, ALP, total bilirubin and decreased liver content of NO and normalized MDA, GSH and SOD. Conclusion: The results of this study revealed the presence of two new compounds and the polar fraction of the plant represent a promising hepatoprotective activity.

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