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Journal of Biological Sciences
Year: 2018  |  Volume: 18  |  Issue: 5  |  Page No.: 251 - 259

Antioxidant and Anti-diabetic Effects of Cumin Seeds Crude Ethanol Extract

Doha Abdou Mohamed, Ibrahim Mohamed Hamed and Karem Aly Fouda    

Abstract: Background and Objective: Diabetes is a metabolic disease associated with hyperglycemia. Diabetes is the major cause of morbidity and mortality worldwide. Chronic hyperglycemia in diabetic patients leads to damage and dysfunction of many organs. The aim of the present research was studying the anti-diabetic potential of crude ethanol extract of cumin seeds (CEEC). Methods: CEEC was prepared. Diabetes was induced in rats by single dose of streptozotocin (STZ). Total flavonoids and total phenolic contents were determined in the CEEC. Free radical scavenging activity of the extract was estimated using DPPH method. Acute toxicity of the CEEC on mice was determined. The effect of CEEC on glucose tolerance was evaluated. Results: The results revealed that total phenolic and total flavonoids were presence in the CEEC by 23.02±0.045 mg GAE g–1 extract and 19±0.132 mg QE g–1 extract, respectively. CEEC showed free radical scavenging activity. Acute toxicity revealed that CEEC was completely safe up to 12 g kg–1 mice. Oral administration of CEEC reduced glycemic levels. CEEC significantly reduced plasma glucose levels in diabetic rats and elevate insulin levels significantly compared with diabetic control. CEEC improved plasma lipid profile, reduced oxidative stress and reduced inflammation in diabetic rats. Conclusion: Crude ethanol extract of cumin seeds may be used as alternative treatment for diabetes. The results indicated that CEEC may be very helpful in the improvement of plasma lipid profile as one of the risk factors for cardiovascular diseases and heart failure in diabetic patients.

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