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Journal of Biological Sciences
Year: 2017  |  Volume: 17  |  Issue: 6  |  Page No.: 247 - 254

Microrna a New Gate in Cancer and Human Disease: A Review

Ghanbar Mahmoodi Chalbatani, Hassan Dana, Elahe Gharagozlou, Habibollah Mahmoodzadeh, Elham Zeinalinia, Omaid Rezaeian, Parisa Pilvar, Milad Ardaneh, Saeed Meghdadi, Fereidoon Memari and Nargesyousefi Rad    

Abstract: MicroRNAs are small noncoding RNAs with lengths of 21-22 nucleotides that participate in post-transcriptional control of gene expression. According to recent studies, 2588 microRNAs have been detected and the list is growing. Furthermore, microRNA (miRNA) plays a major role in regulating biological processes and miRNA in relation to many diseases including cancer. The deregulation connection between miRNA and cancer was discovered in 2002. Today, even more information about the main role that miRNA plays in cancer development has been uncovered, however, there is still a long way to go to understand the functions of all the microRNAs in eukaryotes. In this review, briefly explained miRNA biogenesis and discuss the roles that miRNAs play in cancer development. Finally, discussed how miRNAs can be used as biomarkers and as a new therapeutic approach in cancer.

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