Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Biological Sciences
Year: 2016  |  Volume: 16  |  Issue: 3  |  Page No.: 58 - 64

Blood Glucose Level and Lipid Profile of Streptozotocin-induced Diabetes Rats Treated with Sodium Alginate from Sargassum crassifolium

Amir Husni, Dwi Purwanti and Ustadi    

Abstract: The objective of this study was to evaluate the potential effect of sodium alginate from Sargassum crassifolium on glucose level and lipid profile in streptozotocin-induced diabetes rats. Sodium alginate extract of S. crassifolium 200, 400 and 600 mg kg–1 was administered orally to streptozotocin-induced diabetes rats, once daily for 15 days. The result obtained were then compared with normal control (non-diabetic+normal saline 0.9% p.o), negative control (diabetes+CMC-Na 0.5% p.o) and positive control (diabetic+glibenclamide 5 mg kg–1 p.o). The glucose level, lipid profile and body weight were measured on normal condition (baseline) on 0, 5th, 10th, 15th day and pancreatic histopathological study were done on 15th day. Sodium alginate extract of S. crassifolium had yield 23.82% db, viscosity of 521 cps and a water content of 16.18% db. Sodium alginate 600 mg kg–1 significantly reduce level preprandial glucose, postprandial glucose and total cholesterol compared negative control and did not have significant difference with positive control. Levels of triglycerides and LDL-c throughout the treatment groups had significant differences with the negative control. Meanwhile, the levels of HDL-c throughout the treatment group did not have significant differences. Necrosis was found in all streptozotocin-induced rats. The higher alginate doses given, getting better lower the levels of glucose and total cholesterol.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility