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Journal of Biological Sciences
Year: 2016  |  Volume: 16  |  Issue: 3  |  Page No.: 49 - 57

Effect of Aqueous Extract of Green Tea (Camellia sinensis) on Hematology and Oxidative Stress Biomarkers in Rats Intoxicated with Carbon Tetrachloride

Ibrahim Albokhadaim    

Abstract: The present study aimed to investigate the effects of aqueous extract of green tea (Camellia sinensis) on selected hematological and chemical biomarkers in rats intoxicated with carbon tetrachloride (CCl4). Therefore, 20 rats were fed on standard diet and divided into four groups. Rats in the first and second groups were injected i/p with paraffin oil and received either normal water or aqueous extract of green tea, respectively. Rats in the third and fourth groups were injected i/p with CCl4 and received either normal water or aqueous extract of green tea, respectively. Blood and liver samples were collected at the end of the experiment (5 weeks). Whole blood samples were used for estimation of selected hematological parameters, harvested sera were used for detection of selected biochemical indices and liver tissues were used for estimation of selected oxidative stress biomarkers. Hematological findings revealed that, there was a significant reduction in Total Erythrocytic Count (TEC) and hemoglobin (Hb) concentration with significant increase in Total Leucocytic Count (TLC) in blood of rats that were exposed to CCl4 without treatment with green tea aqueous extract when compared with control. In addition, CCl4 elevated serum transaminases, hepatic lipid peroxidation and hepatic enzymatic antioxidants activities. Oral green tea extract attenuated the detrimental effects of CCl4lain and corrected all examined biomarkers toward the control levels. Further works are recommended for the evaluation of the effect of green tea (Camellia sinensis) on oxidative stress biomarkers at molecular level.

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