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Journal of Biological Sciences

Year: 2015  |  Volume: 15  |  Issue: 3  |  Page No.: 116 - 123

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

Uroko Robert Ikechukwu, Sangodare Rose Simon Adeyi, Muhammad Kabir Hadiza and Asadu Chidimma Lilian


This study evaluates qualitative and quantitative phytochemical properties of Abrus precatorius leaves. The vitamins and therapeutic effect of methanol extract against tetrachloride (CCl4) induced liver damage in male Wistar albino rats. The results of phytochemical and vitamins indicates richness in saponins, tannins, alkaloids and flavonoids with value 30.05±0.22%, while vitamins such as thiamine, riboflavin, niacin, antioxidant and vitamins A, C and E was quantified. The liver damage was observed in the animals with significant increase in ALT, AST and ALP following the in traperitoneal administration of CCl4. The methanol extract caused significant decrease (p<0.05) in the activities of these enzymes in the treated animals relative to positive control that received CCl4 but were not treated. The extract showed potentials to mopping-up of free radicals generated by CCl4. The extract reduced lipid peroxidation in concentration dependent manner. The findings suggests that the extract have the capacity to improving liver functions and liver regeneration at high concentration. The extracts are safe for consumption, abundant phytochemicals and antioxidant vitamins could offer reasonable protections against oxidative stress.

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