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Journal of Biological Sciences
Year: 2014  |  Volume: 14  |  Issue: 4  |  Page No.: 299 - 304

Profiles of Inflammatory Markers for Traumatised and Nontraumatised Incisors During Orthodontic Treatment with Two Archwire Changes

Z. Yamamoto, I.M. Jaafar, R.M.A. Wahab, Z.Z. Ariffin, I.Z.Z. Abidin, S. Senafi and S.H.Z. Ariffin    

Abstract: Orthodontic treatment may cause dental root resorption. The risk of dental root resorption increases in orthodontic treated-traumatised teeth. An approach to monitor root resorption is by monitoring inflammatory markers. Therefore, we observed the profiles of inflammatory markers namely Creatine Kinase (CK), nitric oxide (NO), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) to determine their importance in orthodontic treatment especially in traumatised and nontraumatised incisors. A total of 13 subjects (7 female, 6 male) participated in this study. Samples were collected from gingival crevicular fluid at baseline (M0), 2 weeks after 0.014 NiTi archwire (M1) and 2 weeks after 0.018 NiTi archwire (M2). All enzyme activities were measured spectrophotometrically at 340 nm. Griess assay was used to measure nitric oxide level. The NO concentration and activities of CK, LDH and AST were not significantly different between traumatised and nontraumatised incisors groups during observation period (p>0.05). Compared to M1, NO concentration decreased significantly in M2. Other comparisons of all four markers over period of archwire changes in both traumatised and nontraumatised incisors groups showed no significant differences. Inflammatory markers showed different activities or level as responses to previous archwire usage and archwire changes. All markers are not sensitive enough to be categorized as inflammatory markers during orthodontic treatment with two archwire changes.

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