Enzymatic in vitro Anti-diabetic Activity of Few Traditional Indian Medicinal Plants
Controlling post-prandial hyperglycaemia through enzymatic inhibition of starch degradation is an effective therapeutic approach in the management of diabetes mellitus. To achieve this, twelve indigenous antidiabetic Indian medicinal plants such as Trigonella foenum-graecum, Ocimum sanctum, Aegle marmelos, Plantago ovata, Catharanthus roseus, Alium cepa, Azadirachta indica, Aloe vera, Magnifera indica, Terminalia chebula, Eugenia jambolana and Linum usitatisumum were subjected to sequential solvent extraction and thereafter, 48 fractions were screened for their α-amylase inhibitory potential at three dosage levels in vitro. Out of the 144 samples, Eugenia jambolana water extract showed maximum α-amylase inhibitory activity with IC50 value 1.33 mg mL-1 in comparison with standard drug acarbose (IC50 value 0.86 mg mL-1). Quantitative phytochemical analysis of the lead extract revealed the presence of phenolic content as 69.68 mg tannic acid equivalent g-1 while flavonoidal content as 57.39 mg rutin equivalent g-1. Present study indicated Eugenia jambolana as a potential α-amylase inhibitor in the management of diabetes.
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