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Journal of Biological Sciences
Year: 2013  |  Volume: 13  |  Issue: 5  |  Page No.: 302 - 312

Inclusion Complex of Solid State Aspirin with Fulvic Acid: Dissolution, Permeability, Stability and Preliminary Pharmacological Studies

M.K. Anwer, S. Jamil, M. Ahmad, M.N. Ansari and T.H. Khan    

Abstract: This study was performed on the possibility of novel complexing agent/bioavailability enhancer in the form of complexation of aspirin with fulvic acid. Solid complexes of aspirin-fulvic acid prepared by solvent evaporation, freeze drying and spray drying methods. These complexes were characterized by using differential scanning calorimetry, fourier transform infrared spectroscopy, powder X-ray diffractometry and scanning electron microscopy. In addition, the influences of the fulvic acid on the dissolution, permeation, stability and pharmacodynamics profile of the complexes were studied. In vitro dissolution studies confirmed the successful complexation by the spray drying method in a molar ratio of 1: 1. The prepared optimized complex showed an improvement in stability and permeability (8 times as compared to pure drug). A significant (p<0.05) anti-inflammatory action of the treatment of optimized spray dried (1:1) aspirin complex with fulvic acid was evidenced by inhibition of rat paw edema and anti-ulcerogenic action was measured by lowest score of ulcer index (0.480.08) with significant reduction in ulceration as compared to pure drug. Fulvic acid appears to be beneficial to overcome the problem of stability and bioavailability of aspirin. A highly significant anti-inflammatory and anti-ulcerogenic action was observed by the treatment of optimized complex. Technology has been developed which can be used for improvement formulation of aspirin.

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