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Journal of Biological Sciences
Year: 2011  |  Volume: 11  |  Issue: 8  |  Page No.: 475 - 480

Flavonoid from Intsia palembanica as Skin Whitening Agent

I. Batubara, L.K. Darusman, T. Mitsunaga, H. Aoki, M. Rahminiwati, E Djauhari and K. Yamauchi    

Abstract: This study aims to obtain active compounds from Intsia palembanica with skin whitening activity. I. palembanica methanol extracts were separated using chromatography techniques and yielded 3 flavanols. Isolated compounds along with 6 other flavonoid compounds were analyzed for tyrosinase inhibitory activity and inhibition of melanin cell growth in B16 cell. The results showed that (-)-robidanol is the most potent tyrosinase inhibitor (IC50 monophenolase 8.7 μM; diphenolase 26.6 μM) and inhibit melanin synthesis 46.2% compared to control (at 100 μM). In conclusion, (-)-robidanol is the best compound as a whitening agent.

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