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Journal of Biological Sciences
Year: 2011  |  Volume: 11  |  Issue: 7  |  Page No.: 433 - 441

Synergic Interactions Between Selected Botanical Extracts and Tetracycline Against Gram Positive and Gram Negative Bacteria

W.A. Hussin and W.M. El-Sayed    

Abstract: The potential use of plants as antimicrobial agents in medicine has not been fully exploited. The present study was carried out to investigate the synergic interaction of dichloromethane/methanol extracts from Punica granatum (PG), Thymus vulgaris (TV), Commiphora molmol (CM) and Achillea fragrantissima (AF) with tetracycline against Gram positive (Staphylococcus aureus ATCC 25923 and Bacillus megaterium ATCC 14591) and Gram negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Klebsiella pneumonia ATCC 700603) bacterial strains. All extracts had a significant antibacterial activity against all tested bacteria within concentrations range of (0.1-50 mg/disk). The lowest Minimum Inhibitory Concentration (MIC) recorded was 1 mg mL-1. The recorded MICs values of PG and TV against Gram negative bacteria were higher than those against Gram positive strains. Combination of PG, TV, or CM with tetracycline achieved synergetic interaction against tested bacteria as indicated from fractional inhibitory concentration and confirmed by time kill assays. CM, PG and TV significantly increased the Post Antibiotic Effect (PAE) of tetracycline from 1 h to 3, 4 and 5 h, respectively. The results suggested the use of these plants in extending the lifetime of fading antibiotics.

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