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Journal of Biological Sciences
Year: 2009  |  Volume: 9  |  Issue: 4  |  Page No.: 362 - 366

Spread of Extended-Spectrum Beta-Lactamase Producing Escherichia coli Clinical Isolates in Sanandaj Hospitals

M. Mansouri and R. Ramazanzadeh    

Abstract: The aim of this study was to determine the prevalence of Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia coli and antimicrobial susceptibility pattern of ESBL-producing and non producing strains. We evaluated 158 E. coli strains isolated from various clinical specimens. The double-disk synergy test was performed on the isolates for the detection of ESBL. These genes were confirmed by PCR methods. The prevalence of ESBL-producing E. coli was found as 16.8%. The ESBL-producing isolate rates were 22.2% (6/27) in intensive care units, 22.2% (6/27) in wards and 44.6% (15/27) in outpatients. This study, present the existence of ESBL-producing isolates and high rate of resistance to antibiotics. Clinicians should be familiar with the clinical importance of these enzymes and potential strategies for dealing with them. The results of the study suggest that community acquired control of ESBL-producing E. coli has great importance.

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