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Journal of Biological Sciences
Year: 2009  |  Volume: 9  |  Issue: 3  |  Page No.: 288 - 291

Prevalence of Haemoglobin Variants in Malaria Endemic Northeast India

S.K. Sharma and J. Mahanta    

Abstract: The present study is an attempt to evaluate the relationship of haemoglobinopathies, particularly Hb E and Plasmodium falciparum malaria in northeastern region of India. The diverse autochthonous inhabitant of this part of India exhibits variable gene frequency for βE-globin gene. The geo-climatic condition of the region supports transmission of Plasmodium falciparum malaria in northeastern parts of India. The study revealed that HbE is predominant with a variable gene frequencies in ethnic groups affiliated to Tibeto-Burman linguistic families. Prevalence of Hb E is also associated with the linguistic affiliation of various Tibeto-Burman linguistic families inhabiting in malaria endemic northeast India. We have also observed a positive correlation (R2 = 0.703) of βE-globin gene frequency and mean incidence of Plasmodium falciparum infection (Pf %) in malaria endemic zones.

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