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Journal of Biological Sciences
Year: 2008  |  Volume: 8  |  Issue: 3  |  Page No.: 675 - 678

Hypotensive Effects and Acute Toxicity Property of Methanol Extract of Baissea axillaris Hau. Leaf on Animal Models

M. Idu, O. Timothy, E.K.I. Omogbai and F. Amaechina    

Abstract: The hypotensive and acute toxicity activities of methanol extract of B. axillaris leaves, obtained by soxhlet extraction, were analyzed using animal models. The extract exhibited a dose-dependent reduction in rabbit blood pressure. Basal mean arterial pressure of 115.67 ± 3.60 mm Hg was progressively reduced to 106.22 ± 3.13 and 69.3 ± 2.59 mm Hg by 2.5 and 20 mg kg-1 doses of extract, respectively. Hematological parameters in Wister rats treated with 1, 2 and 4 g kg-1 of extract showed no significant difference, p>0.05. However, lethal dosage was obtained at 8 g kg-1. The need for further evaluation and prospect of the plant in health care was also discussed.

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