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Journal of Biological Sciences
Year: 2008  |  Volume: 8  |  Issue: 6  |  Page No.: 1100 - 1103

The Relationship of Haptoglobin Polymorphism and Cardiovascular Diseases in Some of Iranian Diabetic Patients

P. Ghadam, A. Abadi, A. Asadzadeh, N. Safari, A. Shabani and M. Sharifian    

Abstract: In this study, we found that allelic polymorphism in Hp gene acts as a major determinant of susceptibility for the development of diabetic cardiovascular complications. We studied this gene in 122 Iranian diabetic cardiovascular patients. The results showed that distribution of the Hp phenotypes were found to be in Hardy-Weinberg equilibrium. By using the chi square test we determined the association between Hp allele and diabetic cardiovascular diseases (χ2 = 52.98 p<0.001) and this finding was independent of gender (χ2 = 0.39 p>0.05). The chance of having allele two in diabetic patients with cardiovascular disease was 22.31 (95% CI, 6.18 to 80.5) times more than those with allele one (p<0.0001).

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