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Journal of Biological Sciences
Year: 2008  |  Volume: 8  |  Issue: 6  |  Page No.: 1082 - 1086

Comparison of Hypotensive and Hypolipidemic Effects of Catharanthus roseus Leaves Extract with Nifedipine on Adrenaline Induced Hypertensive Rats

N. Ara, M. Rashid and M.S. Amran    

Abstract: The leaves extract of Catharanthus roseus was investigated for hypotensive and hypolipidemic effects in Adrenaline-Induced Hypertensive Rats (AIHR) and compared with those of nifedipine in a crossover design. The pharmacologically Active components responsible for hypotensive activities were isolated from plant using bioassay guided purification approach and the structure of the compounds were proposed by spectroscopic methods. Catharanthus roseus leaves extract and commercial drug nifedipine were administered through intraperitoneal (i.p) route for one week. Different biochemical parameters such as heart weight, blood glucose level, serum cholesterol level, serum triglyceride level, body weight and the relationships between them were measured. Catharanthus roseus leaves extract at a dose of 30 mg/155 ± 15 g of body weight was injected in rat at every morning during the treatment period. Clinically effective plasma concentration as a hypotensive drug was obtained after the injection of 0.1 mg/155 ± 15 g of body weight of the drug. The Catharanthus roseus leaves extract made significant changes in each cardiovascular parameter after investigation. Catharanthus roseus leaves extract treated animals have shown the hypotensive effects. Hypotensive effects were also shown by nifedipine.

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