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Journal of Biological Sciences

Year: 2008  |  Volume: 8  |  Issue: 6  |  Page No.: 1067 - 1071

Effect of Administration of the Essential Oil from Tagetes minuta L. Leaves in Wistar Rats

O.O. Odeyemi, M.T. Yakubu, P.J. Masika and A.J. Afolayan


The effects of the essential oil from Tagetes minuta leaves at 125, 250, 375 and 500 μL kg-1 b.wt. on some biochemical parameters of Wistar rats were studied. There was no significant difference in packed cell volume, mean corpuscular hemoglobin concentration, monocytes, lymphocytes, eosinophils, basophils, serum alanine transaminase, liver and kidney body weight ratios. However, the 125 μL kg-1 b.wt. resulted in significant decrease in red blood cell and hemoglobin, whereas the same dose produced increase in mean corpuscular volume, mean corpuscular hemoglobin, neutrophils and large unstained cell. Sodium, inorganic phosphorus, conjugated bilirubin, albumin, globulin and total protein at all the doses were not affected while potassium, chloride, urea, creatinine and total bilirubin concentration were increased at certain doses. Whereas the activity of serum gamma glutamyl transferase was significantly increased at all the doses, those of serum aspartate transaminase were increased only at 125 and 500 μL kg-1 b.wt. The kidney-body weight ratio was increased only at 375 and 500 μL kg-1 b.wt. The result showed that the oil of T. minuta had a mild effect on the parameters investigated at certain doses. This dose and parameter specific effects may influence the use of the essential oil from T. minuta as an insecticide against Sitophilus zeamais in maize grains meant for human and animal consumption.

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