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Journal of Biological Sciences
Year: 2008  |  Volume: 8  |  Issue: 6  |  Page No.: 1027 - 1032

Effect of Maternal Diabetes on Hippocampus Neuronal Density in Neonatal Rats

M. Tehranipour and M.R. Khakzad    

Abstract: The present study has been undertaken the effects of maternal diabetes on Hippocampus structure 1 day neonate individual`s rats from diabetic mothers in both control and diabetic groups. Diabetes was induced by stereptozotocin (60 mg kg-1) given by a single intraperitoneal injection to female Wistar rats. Control rats were injected with phosphate buffered saline. In neonates brains rapidly were removed and in all sample the number of neurons in CA1, CA2, CA3 was measured via stereological method in both control and experimental groups. Statistical analysis determines that there is a meaningful reduction in number of neurons in CA3 in neonate of diabetic mothers (p<0.05). That may be the reason for memory problem in these neonates.

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