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Journal of Biological Sciences
Year: 2007  |  Volume: 7  |  Issue: 2  |  Page No.: 457 - 459

Pyruvate Concentration in Serum of Sheep Infected with Trypanosoma congolense

J.S. Neils, E.O. Balogun, A.K.B. Sackey, U.S. Abdullahi and K.A.N. Esievo    

Abstract: The concentration change of pyruvate was studied in serum of uninfected and infected sheep with T. congolense. In the uninfected, the mean concentration of 61.23-76.63 mg L-1 of pyruvate was determined using the DNS method. There was a depressed concentration of pyruvate in the two infected groups (A and B); pyruvate level fell to 25.7 mg L-1 in gp A that was treated immediately after the first peak of parasitaemia while in gp B, the concentrations continued to fall (5.2 mg L-1) until the termination of the experiment. The fall might have been as a result of the utilization of the pyruvate by either the host or its conversion to other compounds. It is therefore concluded that animals use the pyruvate or its converted to another compound during trypanosome infection. The decrease in pyruvate levels may be a possible cause of weakness and eventual death in infected animals.

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