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Journal of Biological Sciences
Year: 2007  |  Volume: 7  |  Issue: 2  |  Page No.: 409 - 412

Antiulcer Activity of Methanolic Extract of Bryophyllum pinnatum in Rats

J.K. Adesanwo, Y. Raji, S.B. Olaleye, S.A. Onasanwo, O.O. Fadare, O.O. Ige and O.O. Odusanya    

Abstract: The effect of Bryophyllum pinnatum leaves extract on indomethacin induced gastric ulceration was determined using 25 male albino rats. Animals were divided into 5 groups of 5 animals each. The control group received 0.5 mL of distilled water and varying doses of the extract were used for the remaining groups (10-40 mg kg-1 body weight). The result showed a significant reduction (p<0.05) in incidence of ulceration and mean basal and histamine (1 mg kg-1) stimulated gastric acid secretion in a dose dependent manner thus justifying the use of Bryophyllum pinnatum as an anti-ulcer agent in folklore medicine.

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