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Journal of Biological Sciences
Year: 2006  |  Volume: 6  |  Issue: 5  |  Page No.: 887 - 892

Evaluation of the Protective Effects of Emilia sonchifolia Linn. (DC.) on Perchlorate-Induced Oxidative Damage

D. Gayathri Devi, Y. Lija, T.R. Cibin, P.G. Biju, V. Gayathri Devi and Annie Abraham    

Abstract: Emilia sonchifolia Linn. (DC.) is a traditionally used medicinal plant seen in most tropical and subtropical regions worldwide. Various parts of the plant are used for the treatment of diseases like asthma, intermittent fevers, breast cancer, ophthalmia, nyctalopia etc. We have isolated the flavonoid fraction from E. sonchifolia (whole plant). Female albino rats were fed with 0.2% sodium perchlorate to induce oxidative stress. The flavonoid fraction of the plant was fed along with sodium perchlorate to another group of animals. The experiment consisted of 30 days. The antiperoxidative effect of the plant material was studied in vivo. The levels of lipid peroxidation products (Thiobarbituric acid reacting substances-TBARS), the activities of the antioxidant enzymes-superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), Glutathione Reductase (GR) and glutathione-S-transferase (GST) as well as the concentration of reduced glutathione (GSH) were determined. The results obtained show that the flavonoid fraction of E. sonchifolia is a potent inhibitor of peroxidative damage and can be used as a therapeutic agent.

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