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Journal of Biological Sciences
Year: 2006  |  Volume: 6  |  Issue: 3  |  Page No.: 527 - 531

Plasmid Profiles of Multidrug Resistant Local Uropathogenic Escherichia coli, Klebsiella spp., Proteus spp. and Pseudomonas spp. Isolates

B.A. Adeniyi, C.C. Amajoyi and S.I. Smith    

Abstract: Fifty-two multidrug resistant local uropathogenic Escherichia coli, Klebsiella spp., Proteus spp. and Pseudomonas spp. isolates were tested for susceptibility to 10 antimicrobial agents. Tetracycline (100.0%) and ampicillin (94.2%) showed the highest rates of resistance and ciprofloxacin (50.0%) demonstrated the lowest. The majority of the multiple drug resistant (MDR) isolates showing concurrent resistance to all 10 agents (n = 17) was a component of 32.7%. A total of 23 antimicrobial resistance patterns was observed. The predominant phenotype (32.7%) amongst the isolates included resistance to ciprofloxacin, cefuroxime, ceftriaxone, ampicillin, gentamicin, nalidixic acid, nitrofurantoin, co-trimoxazole, streptomycin and tetracycline. A 38.5% (n = 10) of the isolates were carrying plasmids of sizes estimated above 2.1 kb. After curing, most of the mutant strains lost their plasmids as was corroborated by their improved susceptibilities. Given that uropathogens are demonstrating increasing antimicrobial resistance, epidemiological investigation using the molecular characterization tools is highly necessary.

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