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Journal of Biological Sciences
Year: 2006  |  Volume: 6  |  Issue: 3  |  Page No.: 521 - 526

Antimicrobial and Antiulcer Activities of Methanol Extract of Allium sativum on Helicobacter pylori

B.A. Adeniyi, F.S. Oluwole and F.M. Anyiam    

Abstract: Methanol extract of Allium sativum was investigated for in vitro antibacterial activity against H. pylori using standard strain ATCC 43504 and three clinical isolates (UCH97009, UCH99041 and UCH99052) and also for anti ulcer effect in rat. All the strains except UCH99041 were inhibited by thefinal concentration of the tested extract (6 mg mL-1) to varying degrees. The Minimum Inhibitory Concentration (MIC) against all susceptible strains ranged between 153 and 625 μg mL-1. Urease activity of both UCH97009 and UCH99052 strains decreased with increase in the concentration of the extract while the cell surface hydrophobicity of two of the strains was reduced by the extract as there was no aggregation of the cell by the extract. SAT titre was >3.0 M. Methanol extract of A. sativum reduced mean ulcer score from 13.63±1.33 in control to 10.06±1.27 in extract treated. The anti- ulcer effect was however not significant (p>0.05). The acute toxicity test (intraperitonial administration) methanol extract in mice gave LD50 of 8.7 g kg-1 body weight. The result indicates that Allium sativum taken at a low dose may have some therapeutics potentials against gastric ulcers associated with H. pylori infection.

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