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Journal of Biological Sciences
Year: 2006  |  Volume: 6  |  Issue: 6  |  Page No.: 1141 - 1145

Antimicrobial and Gastroprotective Activities of Eucalyptus camaldulensis (Myrtaceae) Crude Extracts

B.A. Adeniyi, T.O. Lawal and S.B. Olaleye    

Abstract: The crude extracts of Eucalyptus camaldulensis were investigated for their in vitro antimicrobial and gastro-protective activities in albino rats. The antimicrobial activity was investigated by screening the crude plant extract for activity against Candida albicans and clinically isolated gentamycin resistant wound bacteria viz: Staphylococcus aureus UCH 2600, Escherichia coli UCH 2554, Pseudomonas aeruginosa UCH 2780 and Proteus mirabilis UCH 2773. These microorganisms were susceptible to the crude extracts at a 10 mg mL-1 concentration. The gastroprotective activity of the methanol extract of Eucalyptus camaldulensis (MEEC) was investigated in rats. Gastro protection was evaluated against gastric mucosal damage induced by ethanol/HCl mixture. The Hcl/Ethanol mixture (1.5 mL of 0.15 N HCl in 70% ethanol) caused severe gastric damage with ulcer index 2.7±0.33. Pre-treatment of animals with crude extract of Eucalyptus camaldulensis leaf 200 and 1000 mg kg-1 orally for 1 h significantly reduced the formation of ulcer by the HCl/ethanol mixture with preventive ratios of 56 and 89%, respectively. Ranitidine afforded 92.5% protection. The results suggest that crude extracts of Eucalyptus camaldulensis has both antimicrobial and anti-ulcer properties.

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