Search. Read. Cite.

Easy to search. Easy to read. Easy to cite with credible sources.

Journal of Biological Sciences

Year: 2006  |  Volume: 6  |  Issue: 6  |  Page No.: 1083 - 1087

Study Towards Cellular Degradation Caused by Environmentally Persistent Chemical

S.K. Das, M. Sakakibara, A. Sakurai, J. Bhattacharjee, M.M. Rahman and M.A. Awal


To observe the effect of environmentally persistent chemical formalin on the cells of male genital system as well as reproduction an experiment was conducted in the Department of Anatomy and Histology, BAU, Mymensingh-2202, Bangladesh. Ten percent commercial formalin was used in 12 prepubertal male Black Bengal goats. At fifteen days after a single exposure of formalin, atrophy of testes was observed for the first time and at thirty days after exposure the mean weight, length and width of testes were significantly decreased compared to those of control group. In histopathological observation, it was found that the peripheral tubules were more affected than the central ones. In heavily affected areas, the seminiferous tubules were collapsed or shrunk. Focal or complete necrosis was also noticed in different regions of treated testes. In addition, increased connective tissues with macrophage infiltration were also observed in the interstitial region. Mark eosinophilic staining was also observed in the treated testicular tissue. The sloughed and necrosed seminiferous tubules were also found indicating cellular degradation caused by formalin. Further study is also needed to elucidate the exact mechanism of cellular degradation caused by such environmentally persistent chemicals both in vivo and in vitro.

Cited References Fulltext