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Journal of Biological Sciences
Year: 2005  |  Volume: 5  |  Issue: 4  |  Page No.: 417 - 420

Central Evidence That Neuronal Nitric Oxide and Muscarinic Receptor Influence the Salivary Secretion Induced by Pilocarpine

W.A. Saad, I.F.M.S Guarda, L.A.A. Camargo, W.A. Saad and R.S. Guarda    

Abstract: In this study we focused on the effect of injection of 7-nitroindazol (7NI) a neuronal nitric oxide synthase inhibitor (nNOSI), L-rginine (LA) a nitric oxide donor agent and atropine a muscarinic receptor antagonist, on the salivary secretion, induced by pilocarpine injection into antero ventral third ventricle (AV3V). Rats were anesthetized with 2,2,2-tribromoethanol (200 mg kg-1 b. wt.) and a stainless steel cannula was implanted into their AV3V. The amount of saliva secretion was studied over a ten minute period after injection of pilocarpine into AV3V. Injection of pilocarpine (10, 20, 40, 80, 160 μg/0.5 μL) into AV3V produced a dose-dependent increase in salivary secretion. 7-NI (40 μg/0.5 μL), was injected into AV3V prior to the injection of pilocarpine produced an increase in salivary secretion due to the effect of pilocarpine. LA (30 μg/0.5 μL) was injected into AV3V prior to pilocarpine attenuated the increase in salivary secretion induced by pilocarpine. The injection of atropine (20 μg/0.5 μL) prior to pilocarpine blocked the sialogogue effect of it. All these roles of pilocarpine depend on the release of nitric oxide into the AV3V and circumventricular structures of central nervous system that are implicated in the control of hydroeletrolitic balance of the body. We may also conclude that these structures are involved with the cholinergic excitatory mechanism that induces salivary secretion by implication of muscarinic receptors.

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